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SUBOXONE, THE FILM

It (subutex, temgesic) is a semo-synthetic opioid that is used to treat opioid addiction in higher dosages (>2mg) and tocontrol moderate pain in non-opioid tolerant individuals in lower dosages (200ug.)


Buprenorphine is a Bently-derivative opioid of the phenanthrene-morphine class with extremely high bonding affinity at the u- andk-opioid receptor. It has partial or full agonist activity at the ORL/nociceptin and 8-opioid receptor and competitive angonist activity at the k-opioid receptor.


Now that we have gotten that out of the way. Let's talk about this. In the United States, it has been a Schedule III drug under the United Nations Convention on Psychotropic Substances. since it has been rescheduled from Schedule V just before FDA approval of Suboxone and Subutex.


Reckitt Benckiser first marketed buprenophine under the trade names Temgesic (sublingual/parenteral preparations, no active ingredient additives) and Buprenex (parenteral, no active additives).


Two more recent formulations from Reckitt Benckiser have been approved for opioid addiction treatment throughout the world,instead Methadone. Subutex (white color, oval shape, bitter, no active additives) and It is (orange) color, hexagonal shaped tablet, orange flavored, one part naloxone for every four parts buprenorphine). Subutex and Suboxone are available in 2mg and8mg sublingual dosages.

Go From Suboxone To SuboxoneII

Suboxone contains buprenorphineas well as opioid antagonist naloxone to deter the abuse of tablets by intravenous injection.


Since 2001 buprenorphine is also available transdermally as 35, 52.5 and 70mcg (micrograms) per hour transdermal patchesthat deliver the dose over ninety-six hours.


Other available buprenorphine formulations include a 5, 10 and 20mcg per hour, 7 day patch, marketed as Butrans in the U.S.A.by Purdue Pharma and indicated for the management of moderate to severe chronic pain patients requiring a continuous, aroundthe clock opioid analgesic for an extended period of time.


A novel implantable formulation of buprenorphine (Probuphine), using polymer matrix sustained-release technology, has been developed to offer treatment for opioid dependence while minimizing risks of patient noncompliance and illicit diversion.


In addition to the sublingual tablet, Suboxone is now marketed in the form of a sublingual film, available in both 2mg/0.5 and 8mg/2mgdosages. The makers of Suboxone, Reckitt Benckiser, claim that the film has some advantages over the traditional tablet in that it dissolves faster and unlike the tablet, adheres to the oral mucosa under the tongue, preventing it from being swallowed or falling out;that patients favor its taste over the tablet.

Buprenorphine is a derivative with powerful analgesia and its analgesic effect is due to partial agonist activity, it is less likely to transduce a response in contrast to a full agonist such a morphine. Overdose is unlikely in addicted patients or people with tolerance to opioids who use the drug sublingually as meant in the case of Subutex/Suboxone, especially if there is no alcohol involved. Theuse of alcohol of alcohol with any opioid increases the risk of overdose. One study showed a higher incidence of fatal overdose inpatients who injected both buprenorphine and benzodiazepines, specifically temazepam, together.


Buprenorphine can be safely taken with prescribed benzodiazepine at normal dosages prescribed as long as the patient is tolerant to either opioids or benzodiazepines and the drugs are taken in the dosages prescribed and by the route of administration prescribed, and not injected.


Buprenorphine (Subutex) itself binds more strongly to receptors in the brain than do other opioids, making it more difficult for opioids(or opiates) to react when buprenorphine is in the system.

Go From Suboxone To Heroin-Addiction

Like full agonist opiates, buprenorphine can cause drowsiness, vomiting and respiratory depression. Taking buprenorphine in conjunction with central nervous system depressants in people who are not tolerant to either agent can cause fatal respiratory depression.


People switching from other opiates should wait until mild to moderate withdrawal symptoms are encountered. Failure to do so can lead to the rapid onset of intense withdrawal symptoms, known as precipitated withdrawal. For short acting opioids such as codeine, hydrocodone,oxycodone, hydromorphone, pethidine, heroin, and morphine, 12-24 hours from the last dose is generally sufficient. For longer acting opioids such as methadone, 2-3 days from the last dose is needed to prevent precipitated withdrawal.
Switching from buprenorphine to other opioids is generally safe and can occur immediately. For users of Suboxone, it is advised to wait a few hours from the last dose before switching to other opioids to allow the naloxone and Suboxone to be eliminated from the body (it has a short half-life).

RECREATIONAL USE

Buprenorphine is also used recreationally, typically by opioid users, often by snorting. Recreational users of Suboxone who crush the tablet and snort it report a euphoric rush similar to oter opioids in addition to a slight "upper" -like-effect. Those already using buprenorphine/Suboxonefor opioid addiction therapy find that snorting is only slightly, if any stronger than taking the pill sublingually, although it may have a quicker onset.Those taking it for addiction therapy also report that obtaining euphoria is virtually impossible after the the first few doses.


Although some people do use buprenorphine for purely recreational reasons, the majority of its illicit users use it for addiction therapy. Many people report it being effective in preventing withdrawals in-between doses of their opiate of choice. Illicit users who do not want it on record may also obtain it on the street to use as a less painful method of quitting than "cold-turkey".


Commonly used slang terms are : Sobos, Bupe, Stops, Stop sign, Box, Orange, Sub and Subs.


The Drug Addiction Treatment Act allowed medical professionals to prescribe and administer opioids to manage addiction (maintenance)as well as for short term (defined as 6 months) and long term detoxification. Such use of opioids had been allowed only in specifically registered drug treatment centers providing "Opiate replacement therapy.

THIS IS THE SECOND PART OF THE SUBOXONE SERIES

WELCOME TO YOUR TREATMENT

Opioid dependence is a challenging disease that often requires medication-assisted treatment along with counseling to provide the bestpossibility of success. Suboxone Sublingual Film is an innovation in treatment that helps address some of the existing challenges faced by patients taking Suboxone sublingual tablet form, such as time to dissolve, bad taste, after-taste, and portability.


When you are prescribed Suboxone Film by your physician, you'll also have exclusive access to the Here To Help Program a free patient support program


WHAT YOU NEED TO KNOW ABOUT SUBOXONE FILM

What is Suboxone Film?-----It is a medication indicated for maintenance treatment of opioid dependence in a doctor'soffice setting and should be used as part of a complete treatment plan to include counseling and support

THE BENEFITS OF TREATMENT WITH SUBOXONE FILM


Opioid dependence is a challenging condition---but it can be treated. When medication-assisted treatment is combined with counseling, there isa greater opportunity for treatment success. Suboxone Film provides an evolved patient experience that includes a built-in-support system., the Here To Help Program, which helps patients stay engaged in their treatment, focused on their goals, and connected to resources when they need them 24/7.


The more easily a medication fits into a patients life, the more the patient can focus on the treatment plan. Individually packaged in unit dose,child-resistant pouches, Suboxone Film is easy to carry, faster to dissolve, and preferred.


WHAT IS NALOXONE-----It is a medication that is used to reverse overdose of opioids. It does this by knocking other opioids off the receptors,preventing the negative effects of the misused drug, such as respiratory depression (slowed breathing).


When Suboxone Film is placed under the tongue as prescribed, very little naloxone is absorbed into the bloodstream. The patient should not feel the effects of naloxone. The naloxone in Suboxone Film is there to deter people from injecting the medication. When Suboxone Film is used incorrectly (by injection), its naloxone component can cause withdrawal symptoms to rapidly occur in an individual dependent on a full opioid agonist.

Go From Suboxone To Methadone